• NMR signal enhancement by hyperpolarization techniques

• NMR and related techniques have become indispensable tools with innumerable applications in physics, chemistry, biology and medicine. One of the main obstacles in NMR is its notorious lack of sensitivity, which is due to the low equilibrium polarization of nuclear spins at ambient temperature. To overcome this issue, different hyperpolarization (HP) methods have been established to generate non-Boltzman spin populations and thus increase NMR and MRI signals by several orders of magnitude.

  In our group we use two different polarization techniques: Dynamic Nuclear Polarization (DNP) and Parahydrogen Induced Polarization (PHIP).

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• Anwendungen der Magnetresonanz

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• M. Roth, P. Kindervater, H.-P. Raich, J. Bargon, H. W. Spiess, K. Münnemann, ”Continuous ¹H and ¹³C signal enhancement in NMR and MRI using parahydrogen and hollow fiber membranes”, Angew. Chem. Int. Ed. 2010, 49, 8358 –8362.
• K. Münnemann, H.W. Spiess, "Nuclear magnetic resonance: The art of signal enhancement", Nature Physics 7, 522-523 (2011).
• K. Münnemann, M. Kölzer, I. Blakey, A. K. Whittaker, K. J. Thurecht, “Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)”, Chem. Commun., 48 (10), 1583 (2012)
• M. B. Franzoni, L. Buljubasich, H. W. Spiess, K. Münnemann, „Long-Lived ¹H Singlet Spin States Originating from Para-Hydrogen in Cs-Symmetric Molecules Stored for Minutes in High Magnetic Fields“, J. Am. Chem. Soc. 134, 10393-10396 (2012).
• L. Buljubasich, M.B. Franzoni, K. Münnemann, "Parahydrogen Induced Polarization by Homogeneous Catalysis: Theory and Applications ", Topics in Current Chemistry, 338, 33 (2013).
• O. Neudert, C. Mattea, H. W. Spiess, S. Stapf, K. Münnemann, "Comparative study of ¹H and ¹⁹F Overhauser DNP in fluorinated benzenes", Phys. Chem. Chem. Phys., 15 (47), 20717 – 20726 (2013).
• D. Graafen, S. Ebert, O. Neudert, L. Buljubasich, M.B. Franzoni, J.F. Dechent, K. Münnemann,“¹H NMR Spectroscopy and MR Imaging with Hyperpolarised Substances", Annual Reports on NMR Spectroscopy, 82,  167-215 (2014).
• O. Neudert, M. Reh, H.W. Spiess, K. Münnemann,:“ X-Band DNP hyperpolarization of viscous liquids and polymer melts”, Macromol. Rapid Commun. 36, 885 (2015).

Complete publication list.

K. Münnemann, NMR and MRI sensitivity enhancement by Parahydrogen Induced Polarization, COST Annual Meeting  "Spin Hyperpolarisation in NMR and MRI” & EUROMAR 2014, Zurich, Switzerland, 27^th of June 2014. Invited

K. Münnemann, C. Bauer, J. Schmiedeskamp, H.W. Spiess, W.G. Schreiber, D. Hinderberger „A Mobile DNP Polarizer for Clinical Applications“, ISMRM 16^th Scientific meeting, Toronto, Canada, May 5-9, 2008.

04/2006 - 06/2009

Postdoc in der Radiologie der Universitätsmedizin Mainz

02/2008 - 03/2016

Forschungsgruppenleiterin am Max-Planck-Institut für Polymerforschung in Mainz

seit 04/2016

Nachwuchsgruppenleiterin am Lehrstuhl für Thermodynamik (LTD), Technische Universität Kaiserslautern